python 2.7 - Response variable 'Y' of a Spatial-Temporal dataset in P-Spline smoothing -


i have 1066*640*480 spatial-temporal brain imaging dataset. need model uni-variate p-spline smoothing on dataset. data have observation variable 'x' i.e 3 dimensional array .mat file. in order estimate spline coefficients need know response variable 'y'. can let me know how know response variable ? missing in concept?


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